A Convenient Method for Synthesis of Cyclic Peptide Libraries

Autor: Tran Trung Tran, Gregory T. Bourne, Stephen G. Love, Andreas Rhumann, Justin F. Coughlan, Jonathon L. Nielson, Marc R. Campitelli, Paul J. Darwen, Douglas A. Horton, Mark L. Smythe
Rok vydání: 2005
Předmět:
Zdroj: Peptide Synthesis and Applications ISBN: 9781588293176
DOI: 10.1385/1-59259-877-3:151
Popis: Cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. Owing to the robustness of amide bond chemistry, the ability to explore extensive chemical diversity by incorporation of unnatural and natural amino acids, and the ability to explore conformational diversity, through the incorporation of various constraints, arrays of cyclic peptides can be tailored to broadly sample chemical diversity. We describe the combination of a safety catch linker with a directed-sorted procedure for the synthesis of large arrays of diverse cyclic peptides for high-throughput screening.
Databáze: OpenAIRE