Gastric Hepatoid Adenocarcinoma

Autor: Aikaterini Tsavari, Adamantia Zizi-Sermpetzoglou, E. Moustou, Mavroudis Voultsos, K. Koulia, Athanasios Marinis
Rok vydání: 2013
Předmět:
Zdroj: Hellenic Journal of Surgery. 85:355-359
ISSN: 1868-8845
0018-0092
DOI: 10.1007/s13126-013-0065-x
Popis: Gastric Hepatoid AdenoCarcinoma (GHAC) is a special type of gastric cancer characterized by morphological features similar to hepatocellular carcinoma (HAC). GHAC has been found in different organs such as the stomach, lung, pancreas, oesophagus, papilla of Vater, colon, kidney, uterus and peritoneum. The diagnosis of GHAC is not dependent on production of AFP, but mainly based on recognition of characteristic histologic features. We report the case of a 72-year-old male patient who underwent a total gastrectomy for a large poorly differentiated gastric tumour. The microscopic examination of the tumour showed an adenocarcinoma with two distinct patterns: that of an adenocarcinoma with glandular differentiation and another with a morphological pattern consisting of polygonal neoplastic cells with abundant eosinophilic cytoplasm, prominent nuclei and high mitotic activity. Immunohistochemical staining revealed positive Hep Par1 and AFP, while CK7 and CK20 were negative, the percentage of hepatoid differentiation being about 60%. On the basis of histological and immunohistochemical findings, the diagnosis of hepatoid gastric adenocarcinoma was established. In general, GHACs have an unfavourable prognosis. The majority have already metastasized by the time of diagnosis, usually to the liver and lymph nodes.
Databáze: OpenAIRE
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