Synthesis of Dihydrospiro Furo[2,3-c]pyrazoles Promoted by Hypervalent Iodine in Water
| Autor: | Chiranjeevi Bingi, Nagaraju Medishetti, Krishnaiah Atmakur, Ashok Kale |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Organic Chemistry Iodobenzene Pyrazolone Hypervalent molecule chemistry.chemical_element 010402 general chemistry Iodine 01 natural sciences Aldehyde 0104 chemical sciences chemistry.chemical_compound medicine Michael reaction Organic chemistry Molecule Knoevenagel condensation medicine.drug |
| Zdroj: | Synlett. 29:1037-1042 |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0037-1609321 |
| Popis: | A simple, green protocol has been accomplished for the synthesis of dihydrospirofuro[2,3-c]pyrazoles in aqueous medium involving pyrazolone and aldehydes in a one-pot reaction promoted by bis(acetoxy)iodobenzene (BAIB) at ambient temperature. The protocol presented herein describes a new transformation where two molecules of pyrazolone react with an aldehyde in a Knoevenagel condensation followed by a Michael addition, and the resulting dienol was rearranged to the title compound. High compatibility, easy work-up, and excellent yields are the advantages of this protocol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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