Expression of MAdCAM-1 and PNAd in Inflammatory and MALT Lymphoma Tissues of Ocular Adnexa, Thyroid, Salivary Gland and Lung
| Autor: | Nobuya Ohara, Gui-Shan Jin, Tadashi Yoshino, Yi-Xuan Liu, Tadaatsu Akagi |
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| Rok vydání: | 2004 |
| Předmět: |
endocrine system
Gastrointestinal tract Pathology medicine.medical_specialty biology Salivary gland High endothelial venules Thyroid MALT lymphoma General Medicine medicine.disease digestive system diseases Lymphatic system medicine.anatomical_structure immune system diseases hemic and lymphatic diseases Immunology Addressin biology.protein medicine Lymphocyte homing receptor |
| Zdroj: | Journal of Clinical and Experimental Hematopathology. 44:33-37 |
| ISSN: | 1880-9952 1346-4280 |
| DOI: | 10.3960/jslrt.44.33 |
| Popis: | Mucosa-associated lymphoid tissue (MALT) lymphomas usually arise from acquired MALT induced by chronic inflammation or autoimmune processes. In MALT of the gastrointestinal tract lymphocyte homing mechanisms operate primarily through interactions between integrin, expressed on mucosal lymphocytes, and MAdCAM-1, expressed on endothelium of high endothelial venules (HEV). In the present study, the expression of MAdCAM-1 and peripheral lymph node vascular addressin (PNAd) was examined immunohistochemically in normal, inflamed and MALT lymphoma tissues of various organs. It was shown that MAdCAM-1 was expressed on HEV in the gastrointestinal tract and thyroid that are inflamed or affected with MALT lymphomas, but not in the ocular adnexa, lung, and salivary gland. In contrast, PNAd was consistently expressed in all of the inflammatory or lymphomatous lesions examined, but not in the normal tissues. Expression of MAdCAM-1 on HEY may play an important role in lymphocyte migration at sites of chronic inflammation or MALT lymphoma of the gastrointestinal tract and thyroid. In other organs, PNAd may have the greater role. |
| Databáze: | OpenAIRE |
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