| Autor: |
M. Frederick Hawthorne, Kenneth Shelly, D A Feakes |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
Cancer Neutron Capture Therapy ISBN: 9781475795691 |
| DOI: |
10.1007/978-1-4757-9567-7_2 |
| Popis: |
The slow evolution of effective drug-targeting methodologies for the selective delivery of boron to cancer cells persists as an important obstacle to the development of boron neutron capture therapy.1 Simple boron compounds offer the convenience of availability and ease of synthesis but often exhibit low selectivity and require large injected doses in order to produce the required boron concentrations in tumor. The development of new boron compounds with natural tumor selectivity is problematic. The conjugation of boron-rich moieties to existing tumor-selective substrates often leads to problems with loss of tumor specificity, water solubility, and toxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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