A mild and efficient amidation of cyclic ethers catalyzed by rhodium caprylate

Autor:	Dan-Dan Zhang, Ling He, Qing-Rong Qi, Ling-Hui Gu, Ping Yin
Rok vydání:	2014
Předmět:	chemistry Stereochemistry One pot reaction Nitrene Organic Chemistry Drug Discovery chemistry.chemical_element Biochemistry Medicinal chemistry Rhodium Catalysis
Zdroj:	Tetrahedron. 70:8155-8160
ISSN:	0040-4020
DOI:	10.1016/j.tet.2014.07.082
Popis:	A small quantity of Rh 2 (O 2 CC 7 H 15 ) 4 (2.5 mol % to 0.6 mol %) catalyzed the α-amidation of cyclic ethers under mild conditions, 35 °C, in the presence of electron-withdrawing p -chlorobenzenesulfonamide/PhI(OAc) 2 as the nitrene source, in CH 2 Cl 2 for 4 h. The corresponding N -substituted amino cyclic ethers were successfully obtained in good yields (up to 87% based on 99% conversion) and compatibility with other oxidant sensitive structures in one-pot reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b0fd3b9ec1efb83e08ed057016741454 https://doi.org/10.1016/j.tet.2014.07.082 Zobrazit plný text záznamu Full Text from ScienceDirect