Cardiac Rehabilitation Improves Functional Capacity and Patient-Reported Health Status in Patients With Continuous-Flow Left Ventricular Assist Devices
| Autor: | Meghan Swaffer, Kyle Bronsteen, Steven J. Keteyian, Mauricio Velez, John R. Schairer, Yelena Selektor, Dennis J. Kerrigan, Jonathan K. Ehrman, Celeste T. Williams, Cristina Tita, Clinton A. Brawner, David E. Lanfear, Matthew A. Saval |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Ejection fraction Rehabilitation Randomization business.industry medicine.medical_treatment VO2 max medicine.disease law.invention Randomized controlled trial law Internal medicine Heart failure medicine Physical therapy Cardiology Aerobic exercise Treadmill Cardiology and Cardiovascular Medicine business |
| Zdroj: | JACC: Heart Failure. 2:653-659 |
| ISSN: | 2213-1779 |
| DOI: | 10.1016/j.jchf.2014.06.011 |
| Popis: | Objectives This study examined the effects of a cardiac rehabilitation (CR) program on functional capacity and health status (HS) in patients with newly implanted left ventricular assist devices (LVADs). Background Reduced functional capacity and HS are independent predictors of mortality in patients with heart failure. CR improves both, and is related to improved outcomes in patients with heart failure; however, there is a paucity of data that describe the effects of CR in patients with LVADs. Methods Enrolled subjects (n = 26; 7 women; age 55 ± 13 years; ejection fraction 21 ± 8%) completed a symptom-limited cardiopulmonary exercise test, the Kansas City Cardiomyopathy Questionnaire (KCCQ), a 6-min walk test (6MW), and single-leg isokinetic strength test before 2:1 randomization to CR versus usual care. Subjects in the CR group underwent 18 visits of aerobic exercise at 60% to 80% of heart rate reserve. Within-group changes from baseline to follow-up were analyzed with a paired t-test, whereas an independent t-test was used to determine differences in the change between groups. Results Within-group improvements were observed in the CR group for peak oxygen uptake (10%), treadmill time (3.1 min), KCCQ score (14.4 points), 6MW distance (52.3 m), and leg strength (17%). Significant differences among groups were observed for KCCQ, leg strength, and total treadmill time. Conclusions Indicators of functional capacity and HS are improved in patients with continuous-flow LVADs who attend CR. Future trials should examine the mechanisms responsible for these improvements, and if such improvements translate into improved clinical outcomes. (Cardiac Rehabilitation in Patients With Continuous Flow Left Ventricular Assist Devices:Rehab VAD Trial [RehabVAD]; NCT01584895 ) |
| Databáze: | OpenAIRE |
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