Synthesis and Evaluation of Pyrazole Derivatives as Potent Antinemic Agents

Autor:	N. Jain, N. K. Dhillon, Divya Utreja, G. Kaur
Rok vydání:	2020
Předmět:	biology 010405 organic chemistry Organic Chemistry Halogenation Carbon-13 NMR Pyrazole biology.organism_classification 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry embryonic structures Meloidogyne incognita Root-knot nematode Organic chemistry
Zdroj:	Russian Journal of Organic Chemistry. 56:113-118
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428020010182
Popis:	Pyrazole derivatives were synthesized by bromination of pyrazole, followed by N-alkylation of 4-bromopyrazole. The synthesized derivatives were characterized by microanalytical data and IR and 1H and 13C NMR spectra and were evaluated for their nematicidal activity against the root knot nematode Meloidogyne incognita. The compounds were screened for their egg hatch inhibition and mortality potential, and they showed significant nematicidal activity as compared to the control. 1H-Pyrazol-5(4H)-one was found to be most effective in egg hatch inhibition, and 4-bromopyrazole was found to be most effective in juvenile mortality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b0e24b3743c9fca5ec005314ff0ee8c6 https://doi.org/10.1134/s1070428020010182 Zobrazit plný text záznamu Plný text ve formátu PDF