Laccaridione C, a Bioactive Polyketide from the Fungus Montagnula sp

Autor:	Francisca Vicente, Olga Genilloud, Víctor González-Menéndez, Jesús Martín, Celso Almeida, Ignacio Pérez-Victoria, Nuria de Pedro, Thomas A. Mackenzie, Gloria Crespo, Bastien Cautain, Fernando Reyes
Rok vydání:	2019
Předmět:	Polyketide Bioassay guided fractionation Strain (chemistry) biology Montagnula Stereochemistry Chemistry Fungal strain Fungus Cancer cell lines biology.organism_classification Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Planta Medica International Open. 6:e57-e62
ISSN:	2509-6656 2509-9264
DOI:	10.1055/a-1032-3346
Popis:	The new polyketide laccaridione C (1) was obtained by bioassay-guided isolation of organic extracts of the fungal strain CF-223743, isolated from dung collected in a forest of Grand Comoros Island. Its structure was established using spectroscopic methods, namely HRMS and 1D and 2D NMR. The new compound was tested against seven cancer cell lines, evidencing effective activity against melanoma (A2058) with an IC50 of 13.2 µM, and an increased activity against breast cancer (MCF-7) with an IC50 of 3.7 µM. The strain CF-223743 was taxonomically identified as Montagnula sp. based on ITS/28S analysis
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b0de110354ad456b400fcdefa51b932b https://doi.org/10.1055/a-1032-3346 Zobrazit plný text záznamu