The structural correlates of functional deficits in early huntington's disease
| Autor: | Ralf Reilmann, Damian Justo, Sarah J. Tabrizi, Christine Delmaire, Simon J.A. van den Bogaard, Stéphane Lehéricy, M Sharman, Alexandra Durr, Romain Valabregue, David Craufurd, Eve M. Dumas, C Jauffret, Raymund A.C. Roos, Julie C. Stout |
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| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
Radiological and Ultrasound Technology Putamen Caudate nucleus Parietal lobe 03 medical and health sciences 0302 clinical medicine nervous system Neurology Fractional anisotropy Basal ganglia Cingulum (brain) Radiology Nuclear Medicine and imaging Orbitofrontal cortex Neurology (clinical) Anatomy Prefrontal cortex Psychology Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Human Brain Mapping. 34:2141-2153 |
| ISSN: | 1065-9471 |
| DOI: | 10.1002/hbm.22055 |
| Popis: | Neuropathological studies in Huntington disease (HD) have demonstrated neuronal loss in the striatum, as well as in other brain regions including the cortex. With diffusion tensor MRI we evaluated the hypothesis that the clinical dysfunction in HD is related to regionally specific lesions of circuit-specific cortico-basal ganglia networks rather than to the striatum only. We included 27 HD and 24 controls from the TRACK-HD Paris cohort. The following assessments were used: self-paced tapping tasks, trail B making test (TMT), University of Pennsylvania smell identification test (UPSIT), and apathy scores from the problem behaviors assessment. Group comparisons of fractional anisotropy and mean diffusivity and correlations were performed using voxel-based analysis. In the cortex, HD patients showed significant correlations between: (i) self paced tapping and mean diffusivity in the parietal lobe at 1.8 Hz and prefrontal areas at 3 Hz, (ii) UPSIT and mean diffusivity in the parietal, and median temporal lobes, the cingulum and the insula, and fractional anisotropy in the insula and the external capsule, (iii) TMT B and mean diffusivity in the white matter of the superior frontal, orbital, temporal, superior parietal and post central areas, and (iv) apathy and fractional anisotropy in the white matter of the rectus gyrus. In the basal ganglia, we found correlations between the self paced tapping, UPSIT, TMT tests, and mean diffusivity in the anterior part of the putamen and the caudate nucleus. In conclusion, disruption of motor, associative and limbic cortico-striatal circuits differentially contribute to the clinical signs of the disease. |
| Databáze: | OpenAIRE |
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