Vanadium‐Catalyzed N‐Benzoylation of 2‐Aminopyridines via Oxidative C(CO)−C(CO) Bond Cleavage of 1,2‐Diketones, N→N′ Aroyl Migration and Hydrolysis of 2‐(Diaroylamino)pyridines
| Autor: | P.V. Sri Ramya, Baijayantimala Swain, Ahmed Kamal, Upasana Yadav, Chander Singh Digwal |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Base (chemistry) 010405 organic chemistry Chemistry Organic Chemistry Vanadium chemistry.chemical_element Oxidative phosphorylation 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis Hydrolysis Bond cleavage Aminopyridines |
| Zdroj: | Asian Journal of Organic Chemistry. 7:865-869 |
| ISSN: | 2193-5815 2193-5807 |
| DOI: | 10.1002/ajoc.201800012 |
| Popis: | A one-pot route to synthesize pyridylbenzamides has been developed via vanadium-catalyzed C(CO)−C(CO) bond cleavage of 1,2-diketones with 2-aminopyridines, N→N′ aroyl migration, and hydrolysis of in situ generated 2-(diaroylamino) pyridines. This method offers a simple, neutral, and practical approach to access various medicinally important pyridylbenzamides under base-, additive- and external oxidant-free conditions. |
| Databáze: | OpenAIRE |
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