Weight Gain and Treatment Interruptions with Second-Generation Oral Antipsychotics: Analysis of Patients with Schizophrenia or Bipolar I Disorder

Autor:	Harry Cheng, Michael J. Doane, Thomas Brecht, Leona Bessonova, Amy K O'Sullivan, Gregory Donadio, Kathleen M. Mortimer, Jonathan M. Meyer, Hannah Cummings, David McDonnell
Rok vydání:	2021
Předmět:	Pediatrics medicine.medical_specialty Bipolar I disorder business.industry Overweight medicine.disease Psychiatry and Mental health Median time Schizophrenia Data cloud Baseline weight Low Weight Gain medicine Neurology (clinical) medicine.symptom business Weight gain
Zdroj:	CNS Spectrums. 26:160-160
ISSN:	2165-6509 1092-8529
DOI:	10.1017/s1092852920002576
Popis:	Among patients with schizophrenia (SZ) and bipolar I disorder (BD-I) treated with second-generation antipsychotics (SGAs), clinically-significant weight gain (CSWG) and treatment interruptions (TIs) are challenges that may result in morbidity/mortality.CSWG and TIs were assessed among patients who initiated oral SGAs of moderate-to-high weight gain risk (no exposure to index SGAs/first-generation antipsychotics for =12 months) using medical records/claims (OM1 Data Cloud; January 2013-February 2020). Outcomes included CSWG (=7% increase in baseline weight) and TIs (switches [to SGAs of low weight gain risk/long-acting injectables] or discontinuations [no SGAs for >30 days]). Descriptive analyses included proportions of patients with CSWG and TIs, and median time to these outcomes.Approximately three-quarters of patients were overweight/obese at baseline (SZ: N=8,174; BD-I: N=9,142). Within 3 months of SGA initiation, 12% of all patients experienced CSWG. For patients on treatment with index SGAs for >6 months (SZ: 29%; BD-I: 27%), 28% (SZ) and 30% (BD-I) experienced CSWG during follow-up. Median time to CSWG was 14 weeks. CSWG results were numerically similar among patients with SZ and BD-I.Over 96% of patients had TIs during follow-up (median time of 12 [SZ] and 13 [BD-I] weeks). Among patients with CSWG and subsequent TIs and weight measurements, 74% did not return to baseline weight after interrupting treatment; the remainder returned to baseline weight with median times of 38 (SZ) and 39 (BD-I) weeks. Results suggest that most patients with CSWG do not return to baseline weight after stopping treatment with oral SGAs of moderate-to-high weight gain risk.Funding. Alkermes, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b0d505f87e8ba5a7b8704b938364ca45 https://doi.org/10.1017/s1092852920002576 Zobrazit plný text záznamu