Laxative Activity of the Hot-Water Extract Mixture of Hovenia dulcis Thunb. and Phyllostachys pubescens Mazel in Chronic Constipation Model SD Rats
| Autor: | Kyo-Nyeo Oh, Chulyung Choi, Sangoh Ban, Ju-Seon Yong, Ro-Dong Park, Miri Kim, Choi Eun Jin, Hui-Seop Lee, Hong Ji Ae, H. B. Lee, Yu-Jin Kim, Myung-A Jung, Dool-Ri Oh, Seong-Il Kim |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Loperamide Chronic constipation Constipation Traditional medicine Normal diet biology medicine.medical_treatment Laxative General Medicine biology.organism_classification 01 natural sciences Applied Microbiology and Biotechnology 010608 biotechnology medicine medicine.symptom Bisacodyl Feces Biotechnology medicine.drug Hovenia dulcis |
| Zdroj: | Journal of Microbiology and Biotechnology. 30:649-661 |
| ISSN: | 1738-8872 1017-7825 |
| DOI: | 10.4014/jmb.1911.11051 |
| Popis: | This study examined the laxative effects of hot-water extracts of Hovenia dulcis Thunb. (HD), Phyllostachys pubescens Mazel (PM), and a 2:8 mixture of both (HP) in two chronic constipation models. For the loperamide-induced constipation model, animals were divided into an untreated group, negative control group (loperamide 4 mg/kg), positive control group (bisacodyl 4 mg/kg) group, and six treatment groups (HP 100 or 400, HD 50 or 100, and PM 100 or 400 mg/kg). For the low-fiber diet-induced constipation model, animals were divided into an untreated group (normal diet), negative control group (low-fiber diet), positive control group (Agio granule, 620 mg/kg), and the same treatment groups. Fecal number, weight, fecal water content, and intestinal transit ratio were higher in the groups treated with HP, HD, and PM than in the groups treated with loperamide or low-fiber diet. Thickness of colon mucosa and muscle layers were increased in the treated groups. Colon tension increased in the HP groups, and [Ca2+]i measurements using fura-2 as an indicator showed that HP inhibits ATP-mediated Ca2+ influx in IEC-18 cells. These results showed that the HP mixture has laxative activity by increased mucin secretion and inducing contractile activity and relaxation. It may be a useful therapeutic strategy for ameliorating in chronic constipation. |
| Databáze: | OpenAIRE |
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