ChemInform Abstract: The Phthalation of 2-Amino-2-deoxy-D-glucose and N-Methyl-1-amino-1-deoxy-D-glucitol: Conversion of the Products to Organotin Derivatives. A Ready Migration of Acetyl from Oxygen to Nitrogen under Neutral Conditions

Autor:	Robert C. Poller, Atula Patel
Rok vydání:	1988
Předmět:	Acetic anhydride chemistry.chemical_compound chemistry chemistry.chemical_element General Medicine 1-amino-1-deoxy-D-glucitol 2-Deoxy-D-glucose Oxygen Medicinal chemistry Nitrogen Catalytic hydrogenation Benzyl chloroformate
Zdroj:	ChemInform. 19
ISSN:	0931-7597
DOI:	10.1002/chin.198827300
Popis:	N-Phthalation of 2-amino-2-deoxy-D-glucose was followed by replacement of the acidic proton by tributyl- and triphenylstannyl groups. A similar reaction with 1-(methylamino)-1-deoxy-D-glucitol failed and successive treatment with benzyl chloroformate and acetic anhydride followed by catalytic hydrogenation showed that a 1,4 O N acetyl migration had occurred. Phthalation and stannylation succeeded under different conditions.
Databáze:	OpenAIRE
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