ADI-PEG 20 and FOLFOX6: A phase 1 study in pts (pts) with advanced hepatocellular carcinoma (HCC)

Autor:	Khrystyna Uhlitskykh, James J. Harding, Ghassan K. Abou-Alfa, Xiaoxing Feng, Eileen M. O'Reilly, Jessica Frick, John S. Bomalaski, Richard K. G. Do, Ellen Hollywood, Casey R. Hamilton, Emily Valentino, Peter Justin Wan, Chien-Feng Li, Amanda Johnston
Rok vydání:	2018
Předmět:	Cancer Research Oncology Arginine business.industry Hepatocellular carcinoma Pyrimidine metabolism PEG ratio Cancer research Medicine business medicine.disease DNA Damage Repair Preclinical data
Zdroj:	Journal of Clinical Oncology. 36:4085-4085
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2018.36.15_suppl.4085
Popis:	4085Background: Arginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways, and preclinical data indicate that pairing pegylated arginine deaminase (ADI-PEG 20) ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b0ca61ba936e0b63842b42a49fea68ed https://doi.org/10.1200/jco.2018.36.15_suppl.4085 Zobrazit plný text záznamu