The effect of propargylic substitution on the activation and aromatization of enediynes
| Autor: | Kahnie Pham, Mark D. Wittman, Nada Zein, Wyle Solomon, Harold Mastalerz, Dolatrai M. Vyas, William C. Rose, Leung Kinwa, John F. Kadow |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Antitumor activity
chemistry.chemical_classification Bicyclic molecule Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Substitution (logic) Aromatization Substituent Pharmaceutical Science Biochemistry chemistry.chemical_compound Drug Discovery Propargyl Thiol Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:2925-2928 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80841-6 |
| Popis: | The thiol activation and aromatization of bicyclo[7.1.0]enediynes was found to be dependent of the nature of the propargyl substituent. These effects are correlated to antitumor activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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