Fibrinolytic effect of gemfibrozil versus placebo administration in response to venous occlusion
| Autor: | A V Panno, R. De Simone, R Cordova, Gino Avellone, Giandomenico Bompiani, G. Raneli, V. Di Garbo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Factor VII business.industry Hypertriglyceridemia Hematology Fibrinogen medicine.disease Placebo Group A Gastroenterology Venous stasis Coronary artery disease chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Gemfibrozil business medicine.drug |
| Zdroj: | Fibrinolysis. 7:416-421 |
| ISSN: | 0268-9499 |
| DOI: | 10.1016/0268-9499(93)90068-7 |
| Popis: | Impact of hypertriglyceridemia on atherosclerotic vascular disease and thromboembolic events is recently emphasized by primary prevention studies on the development of coronary artery disease. A randomized double-blind study was carried out with gemfibrozil (600 mg b.i.d.) versus placebo in 20 patients (12 males and 8 females, age 52±3 years, BMI 24.2±0.4) suffering from primary hypertriglyceridemia (Fredrickson's type IV). After a 4-week stabilization period in which administration of lipid-lowering drugs was stopped and an isocaloric diet was prescribed, patients were randomized into two groups. Each group was treated for a 12 week period with gemfibrozil (10 patients) or placebo (10 patients) in a double-blind fashion. Every 4 weeks triglycerides, total cholesterol, HDL-cholesterol, blood glucose and Apolipoproteins A1 and B were determined. At baseline and at the end of the treatment period a venous occlusion test was performed in all subjects. Before and after 10 min venous stasis were measured: t-PA antigen, PAI activity, fibrinogen, plasminogen, Factor VII and haematocrit. In the gemfibrozil-treated group a significant decrease of triglycerides and a significant increase of HDL-C was found. During gemfibrozil treatment a significant reduction of Factor VII, fibrinogen and plasminogen levels either before or after venous occlusion was also observed. After 12 weeks of treatment in the gemfibrozil group the release of t-PA in response to venous occlusion was significantly higher and plasma PAI activity was significantly lower than in placebo group, suggesting a profibrinolytic effect of the drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|