Induction of Cardiovascular Malformations by Leupeptin in the Rat
| Autor: | Akihiko Kodama, Shozo Oku, Takatoshi Yamasaki, Toshio Tachikura, Makoto Nakamura, Koichiro Miyata, Shen‐Fang Chen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Embryology
medicine.medical_specialty Anophthalmia medicine.medical_treatment Leupeptin General Medicine Biology medicine.disease Microphthalmia Resorption stomatognathic diseases chemistry.chemical_compound Endocrinology stomatognathic system chemistry Internal medicine Pediatrics Perinatology and Child Health medicine Gestation Diaphragmatic hernia Trypan blue Saline Developmental Biology |
| Zdroj: | Congenital Anomalies. 31:41-45 |
| ISSN: | 1741-4520 0914-3505 |
| DOI: | 10.1111/j.1741-4520.1991.tb00357.x |
| Popis: | The teratogenic effects of leupeptin on the rat embryonic heart were examined. Wistar rats were injected with 30mg/kg of leupeptin, 50mg/kg of leupeptin, and 2.5ml/kg of normal saline (control group) on days 9 and 10 of gestation. Term fetal weight was significantly lower in the leupeptin groups than in controls. At leupeptin 30mg/kg, the resorption rate, incidence of malformation, and incidence of cardiovascular (CV) malformation were 13.2%, 34.8%, 16.7%, respectively. At leupeptin 50 mg/kg, the resorption rate, incidence of malformation, and incidence of CV malformation were 19.7%, 81.4%, 36.3%, respectively. The most common malformations were hydrocephaly, anophthalmia, microphthalmia, VSD, ASD, hydronephrosis, and diaphragmatic hernia. Multiple organ systems were affected. Malformation types were similar to those induced by anti-kidney antiserum (AKS) and trypan blue (TB). |
| Databáze: | OpenAIRE |
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