Zinc finger protein 521, a new player in bone formation
| Autor: | Kei Yamana, Meilin Wu, Hiroaki Saito, Azeddine Atfi, Roland Baron, Riku Kiviranta, Diego Correa, Eric Hesse |
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| Rok vydání: | 2010 |
| Předmět: |
musculoskeletal diseases
Zinc finger Gene knockdown Periosteum medicine.medical_specialty Chemistry General Neuroscience Mesenchymal stem cell Osteoblast medicine.disease General Biochemistry Genetics and Molecular Biology Cell biology RUNX2 Bone morphogenetic protein 7 Osteopenia medicine.anatomical_structure Endocrinology History and Philosophy of Science Internal medicine medicine |
| Zdroj: | Annals of the New York Academy of Sciences. 1192:32-37 |
| ISSN: | 0077-8923 |
| Popis: | Exploration of anabolic pathways in osteoblasts revealed that Zfp521, a 30-zinc finger protein, is highly expressed at the periphery of mesenchymal condensations and in developing bones. In these structures it is expressed in chondroblasts, prehypertrophic chondrocytes, the periosteum, osteoblasts, osteoblast precursors, and osteocytes. Forced expression of Zfp521 in osteoblasts in vivo increases bone formation and bone mass, whereas preliminary data suggest that germline deletion leads to osteopenia. In contrast, overexpressing Zfp521 in vitro antagonizes, and knockdown favors, osteoblast differentiation and nodule formation. Zfp521 expression is inhibited by bone morphogenetic protein-2 and stimulated by parathyroid hormone-related protein. Mechanistically, Zfp521 binds to Runx2, repressing its transcriptional activity. These data support the hypothesis that Zfp521 both opposes the progression of precursors and promotes the maturation and function of mature osteoblasts. The balance between Zfp521 and Runx2 may therefore contribute to the regulation of osteoblast differentiation and bone formation. |
| Databáze: | OpenAIRE |
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