Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers
| Autor: | Alessi R, Dennis W. Coalson, Young Cj, G. Goldsher, J. L. Lichtor, Conley Km, James P. Zacny, Jeffrey L. Apfelbaum |
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| Rok vydání: | 1996 |
| Předmět: |
inorganic chemicals
Pharmacology Psychomotor learning Subjective effects business.industry Visual analogue scale organic chemicals Nitrous oxide equipment and supplies Placebo Psychiatry and Mental health chemistry.chemical_compound chemistry Anesthesia Digit symbol substitution test Healthy volunteers bacteria Medicine Tingling business |
| Zdroj: | Behavioural Pharmacology. 7:194 |
| ISSN: | 0955-8810 |
| Popis: | The present study examined the subjective, psychomotor and reinforcing effects of 10%, 20%, 30% and 40% nitrous oxide in oxygen in 16 healthy volunteers using a choice procedure in which sampling (e.g. 20% nitrous oxide and oxygen-placebo) and choice trials (e.g. 20% nitrous oxide vs. oxygen placebo) were within the same session. Across the four-session study, nitrous oxide dose was varied. Nitrous oxide in a dose-related manner altered subjective effects (e.g. increased visual analog scale ratings of "high", "stimulated" and "tingling") and decreased performance on the Digit Symbol Substitution Test. 10%, 20%, 30% and 40% nitrous oxide were chosen over oxygen by 6, 7, 7 and 8 subjects, respectively. We conclude that nitrous oxide across a range of subanesthetic doses did not function as reinforcer in the majority of subjects tested. |
| Databáze: | OpenAIRE |
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