Remarkable Activation of an Enzyme by (R)-Pyrrolidine- Substituted Imidazolium Alkyl PEG Sulfate

Autor:	Motoi Kawatsura, Toshiyuki Itoh, Yoshikazu Abe, Takuya Hirakawa, Nagisa Okano, Shuichi Hayase, Shino Nakajima, Yoshihiko Hirose
Rok vydání:	2008
Předmět:	chemistry.chemical_classification biology Salt (chemistry) General Chemistry biology.organism_classification Medicinal chemistry Pyrrolidine Enzyme catalysis chemistry.chemical_compound Burkholderia chemistry PEG ratio biology.protein Organic chemistry Reactivity (chemistry) Lipase Alkyl
Zdroj:	Advanced Synthesis & Catalysis. 350:1954-1958
ISSN:	1615-4169 1615-4150
DOI:	10.1002/adsc.200800382
Popis:	The chiral pyrrolidine-substituted imidazolium cetyl-PEG10-sulfate (D-ProMe) derived from D-proline worked as an excellent activating agent of Burkholderia cepacia lipase; it is particularly interesting that the D-isomer of the imidazolium salt worked better than the L-isomer. This suggests that the imidazolium cation group directly interacts with the enzyme protein and causes preferable modification of the reactivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b0a35d4470ab600b50c2b37f6c0e5e29 https://doi.org/10.1002/adsc.200800382 Zobrazit plný text záznamu Plný text