Achiral internucleoside linkages: CH2-CH2-NH and nH-CH2-CH2 linkages
| Autor: | D. A. Upson, W.C. Schairer, L. I. Kruse, M. Sardaro, T.J. Caulfield, Ashis K. Saha, C.V.C. Prasad, A. Yawman, Prouty Catherine P |
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| Rok vydání: | 1993 |
| Předmět: |
Antisense DNA
Nuclease biology Stereochemistry Oligonucleotide Dimer Organic Chemistry Clinical Biochemistry Pharmaceutical Science Desoxyribonucleotide Biochemistry Molecular hybridization chemistry.chemical_compound Deoxyribonucleotide chemistry Drug Discovery Sense (molecular biology) biology.protein Molecular Medicine lipids (amino acids peptides and proteins) Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:2771-2776 |
| ISSN: | 0960-894X |
| Popis: | The synthesis of CH2-CH2-NH and NH-CH2-CH2 internucleoside linkages are described. Antisense oligonucleosides containing these dimer modifications hybridized to the sense sequence. Furthermore incorporation of these backbone modifications enhanced the nuclease resistance of the antisense strand. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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