Oxidative Stress, Metabolic Syndrome and Alzheimer’s Disease
| Autor: | Karla Carvajal, Luz del Carmen Camacho-Castillo, Danira Toral-Rios, Victoria Campos-Peña, Bryan V. Phillips-Farfan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty biology business.industry Tau protein Inflammation Blood–brain barrier medicine.disease medicine.disease_cause 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology medicine.anatomical_structure Insulin resistance Internal medicine medicine biology.protein Dementia medicine.symptom Metabolic syndrome business 030217 neurology & neurosurgery Neuroinflammation Oxidative stress |
| Zdroj: | Biochemistry of Oxidative Stress ISBN: 9783319458649 |
| DOI: | 10.1007/978-3-319-45865-6_23 |
| Popis: | Oxidative stress, neuroinflammation, insulin signaling deficiency and vascular alterations are common features of many neurodegenerative disorders. Oxidative damage induces chronic inflammation, this condition may lead to insulin resistance and damage to the blood brain barrier (BBB), leading to an exacerbation of central inflammation, causing cognitive dysfunction eventually resulting in dementia. The major cause of dementia affecting the elderly is Alzheimer’s disease, the most common cause of disability characterized by a progressive loss of memory and cognitive function. Neuropathologically, Alzheimer’s disease is characterized by abnormal deposition of the amyloid β (Aβ) peptide and intracellular accumulation of neurofibrillary tangles (NFT) of hyper-phosphorylated tau protein. It has been proposed that Aβ and NFT generate the neuronal damage that leads to cognitive failure, through the generation of reactive oxygen species (ROS). Alternatively, it has been suggested that oxidative damage precedes the accumulation of Aβ, NFTand other alterations such as vascular malfunction and metabolic syndrome. This chapter discusses the main molecular mechanisms associated to oxidative stress, metabolic syndrome and their relationship with Alzheimer’s disease. We also include promising therapeutic strategies. |
| Databáze: | OpenAIRE |
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