| Autor: |
Hartl, Christina, Bertschi, Adrian, Puerto, Regina, Andresen, Carolin, Cheney, Emily, Mittendorf, Elizabeth, Guerriero, Jennifer, Goldberg, Michael |
| Rok vydání: |
2019 |
| DOI: |
10.6084/m9.figshare.9178682.v1 |
| Popis: |
Figure S4. Chemotherapy induces an increase in granulocytic but not monocytic MDSCs. Mice were inoculated orthotopically with ID8-Vegf-Defb29 ovarian cancer cells. Eight days later, the mice were injected with vehicle (Veh) or chemotherapy (Chemo). Two days later, peritoneal cells were harvested and assessed by flow cytometry. (a) Increased numbers of granulocytic MDSCs (Ly6G+Ly6C+) are observed following chemotherapy. (b) Numbers of monocytic MDSCs (Ly6G−Ly6C+) and their expression of immunosuppressive ARG1 and IL-10 are quantified. The experiment was performed twice with n = 4 biological replicates. Statistics were calculated using a two-sided unpaired t-test. Data are presented as mean ± SEM **** p ≤ 0.0001. (PDF 78 kb) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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