Dopamine sensitivity of hypothalamic arcuate neurons and their role in the regulation of pituitary gonatropic function
| Autor: | V. N. Babichev, V. Ya. Ignatkov |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Estrous cycle
endocrine system medicine.medical_specialty Chemistry General Medicine General Biochemistry Genetics and Molecular Biology Plasma LH level Endocrinology Hypothalamus Dopamine Internal medicine medicine Luteinizing hormone hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 84:1534-1537 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00801666 |
| Popis: | The effect of microiontophoretic injection of dopamine (DA) into the arcuate region of the hypothalamus on single unit activity and the plasma and pituitary levels of luteinizing hormone (LH) was investigated in rats in various stages of the estrous cycle. No significant differences in the number of neurons responding by activation or inhibition or not responding to DA could be observed in the course of the estrous cycle. However, in the first half of the day of proestrus (P) a significant increase in the number of neurons responding by activation to microiontophoretic injection of DA was observed. In all stages of the estrous cycle except the second half of P the activation response of the neurons was coupled with elevation of the plasma LH level. A significant rise in the LH level in the pituitary in response to microiontophoretic injection of DA into the hypothalamic arcuate region was observed only in stage diestrus 2. |
| Databáze: | OpenAIRE |
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