Short-Chain Fatty Acids Induce Pro-Inflammatory Cytokine Production Alone and in Combination with Toll-Like Receptor Ligands
| Autor: | Alan L. Landay, Douglas Gilbert, Paria Mirmonsef, G T Spear, Mohammad R. Zariffard, Hadijat Makinde |
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| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Toll-like receptor Reactive oxygen species medicine.medical_treatment Immunology Human immunodeficiency virus (HIV) Obstetrics and Gynecology Inflammation Biology medicine.disease medicine.disease_cause Microbiology Cytokine Reproductive Medicine chemistry medicine Immunology and Allergy Cytokine secretion Anaerobic bacteria medicine.symptom Bacterial vaginosis |
| Zdroj: | American Journal of Reproductive Immunology. 67:391-400 |
| ISSN: | 1046-7408 |
| Popis: | Problem Short chain fatty acids (SCFAs), produced at relatively high levels by anaerobic bacteria in bacterial vaginosis (BV), are believed to be anti-inflammatory. BV, a common alteration of the genital microbiota associated with increased susceptibility to HIV infection, is characterized by increased levels of both pro-inflammatory cytokines and SCFAs. We investigated how SCFAs alone or together with TLR-ligands affected pro-inflammatory cytokine secretion. |
| Databáze: | OpenAIRE |
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