Synthesis of 14C-labelled 2-[4-(p-fluorobenzoyl)piperidin-1-yl]-2′-acetonaphthone hydrochloride (E-2001-14C)

Autor:	Mannen Mishima, Hachiro Sugimoto, Norio Karibe, Takaharu Nakamura
Rok vydání:	1989
Předmět:	chemistry.chemical_compound chemistry Pharmacokinetics Hydrochloride Organic Chemistry Drug Discovery Glutamate receptor Organic chemistry Radiology Nuclear Medicine and imaging Biochemistry Spectroscopy Analytical Chemistry
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 27:417-421
ISSN:	0362-4803
DOI:	10.1002/jlcr.2580270408
Popis:	14C-labelled 2-[4-(p-fluorobenzoyl)piperidin-1-yl]-2′-acetonaphthone hydrochloride (4), a glutamate release inhibitor for studying the pharmacokinetic profiles of E-2001, was synthesized in two steps using 2-bromo-2′-[carbonyl-14C]-acetonaphthone (1) as the labelled starting material.
Databáze:	OpenAIRE
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