ChemInform Abstract: Deprotonative Metalation of Chlorothiophene with Grignard Reagents and Catalytic cis-2,6-Dimethylpiperidine under Mild Conditions

Autor:	Atsunori Mori, Atsushi Sugie, Kenji Ide, Keisuke Shono, Shunsuke Tamba
Rok vydání:	2013
Předmět:	chemistry.chemical_compound chemistry 2 6-Dimethylpiperidine Metalation Reagent Aryl Organic chemistry General Medicine Thiophene derivatives Medicinal chemistry Catalysis
Zdroj:	ChemInform. 44
ISSN:	0931-7597
DOI:	10.1002/chin.201339102
Popis:	The title process affords thienyl-Grignard reagents which undergo Pd-catalyzed coupling with aryl bromides to form 5-substituted products with the C—Cl bond remaining intact.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b06a52640a49761b9df17d5c0d2f8fd6 https://doi.org/10.1002/chin.201339102 Zobrazit plný text záznamu Plný text