Use of buprenorphine in HIV-infected injection drug users: negligible impact on virologic response to HAART
| Autor: | David Vlahov, H. Gallais, Yolande Obadia, G. Lepeu, M P Carrieri, Pierre Dellamonica, Bruno Spire |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology business.industry virus diseases Toxicology medicine.disease biology.organism_classification Virology Substance abuse Psychiatry and Mental health Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine Pharmacology (medical) Viral disease Sida business Viral load Cohort study Methadone medicine.drug Buprenorphine |
| Zdroj: | Drug and Alcohol Dependence. 60:51-54 |
| ISSN: | 0376-8716 |
| DOI: | 10.1016/s0376-8716(00)80007-1 |
| Popis: | Some HIV-infected injecting drug users (IDUs) on drug abuse maintenance treatment have access to highly active antiretroviral therapy (HAART); this raises questions about the effects of individual treatments on the efficacy of HAART. The French Cohort Study of HIV-infected IDUs — MANIF-2000 — allowed one to assess whether buprenorphine differentially impacts efficacy of HAART. Of the 103 HAART-treated patients, (excluding active IDUs and patients on methadone), 20 were on buprenorphine substitution treatment and 83 were ex-IDUs. A linear regression model used the differences in viral load titre before and after treatment initiation, as a dependent variable, and showed that buprenorphine treatment was not significantly associated with viral load trend. This was also the case when adjusting for other potential confounders, and suggests that there is no major short-term influence of buprenorphine on HIV viral load in HAART-treated patients. |
| Databáze: | OpenAIRE |
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