A Longitudinal Study of Cytomegalovirus Infection in Human Immunodeficiency Virus Type I-Seropositive Homosexual Men: Molecular Epidemiology and Association with Disease Progression
| Autor: | Roger Detels, Barbara R. isscher, Zhiyuan Liu, James D. Cherry, Janice P. Dudley, Karen Hennessey, Charles T. Leach |
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| Rok vydání: | 1994 |
| Předmět: |
Longitudinal study
Molecular epidemiology biology business.industry Congenital cytomegalovirus infection virus diseases Semen medicine.disease Asymptomatic Virology Confidence interval Infectious Diseases Acquired immunodeficiency syndrome (AIDS) Immunoglobulin M Immunology biology.protein Immunology and Allergy Medicine medicine.symptom business |
| Zdroj: | Journal of Infectious Diseases. 170:293-298 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/170.2.293 |
| Popis: | Cytomegalovirus (CMV) isolates from 234 asymptomatic human immunodeficiency type 1 (HIV-1)-positive men were analyzed for molecular relatedness using junctional hybridization. Of isolates shed simultaneously at two or more body sites, 36% from 22 men were different. Of 180 isolates collected from 67 men over 15 months, different strains were isolated serially from 27 men (40%), most from semen. After follow-up of 58 months (mean), the relative hazard of HIV infection progressing to AIDS was 1.8 (95% confidence interval [CI], 0.9-3.7) for men shedding the same strain of CMV and 3.0 (95% CI, 1.4-6.1) for men shedding different strains compared with men not shedding CMV in semen. The prevalence of CMV-specific IgM was higher in men shedding different versus same CMV strains (32% vs. 18%; P = .244). Thus, presence of multiple CMV strains in HIV-1-positive homosexual men is associated with progression to AIDS, possibly via activation of HIV-1-infected CD4 cells. |
| Databáze: | OpenAIRE |
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