| Popis: |
Introduction: Pleomorphic adenoma (PA) is a tumor with a mix of components (epithelium-mesenchymal). It occurs more frequently in both the larger and smaller salivary glands, and less frequently in the lacrimal glands. The transformation of PA into high-grade Ductal carcinoma involves a series of histopathological, morphological, and molecular mechanisms, so that its occurrence is rare, nevertheless, the mortality rate is still high. Surgery in conjunction with adjuvant radiotherapy has been shown to be effective in locoregional disease control (LDS); however, the multimodal treatment indicated in the literature remains a controversial issue. Case Report: The present case report aims to describe our experience with the multimodal treatment of an atypical presentation of transformation of PA of the lacrimal gland into a rapidly evolving high-grade ductal carcinoma, and to describe the proposed adjuvant radiation treatment. Conclusion: Adjuvant radiotherapy is a feasible alternative for locoregional control of the disease, irrespective of the anatomopathologic characteristics of the tumor. Randomized clinical trial studies are recommended for an accurate assessment of the impact of multimodal treatment with respect to overall survival rates, locoregional survival, and disease-free survival. |
