ChemInform Abstract: Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones

Autor:	Chun‐Yan Li, Wei-Ping Deng, Wu-Lin Yang, Fu-Sheng He, Xingxin Yu, Fei-Fei Tang
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Chemistry Ligand 1 3-Dipolar cycloaddition General Medicine Medicinal chemistry Cycloaddition Pyrrole derivatives Pyrrolidine Catalysis Stereocenter
Zdroj:	ChemInform. 47
ISSN:	0931-7597
Popis:	A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to 5-alkylidene thia(oxa)zolidine-2,4-diones catalyzed by a chiral N,O-ligand/Cu(CH3CN)4BF4 system is reported, affording structurally novel spirocyclic pyrrolidine-thia(oxa)zolidinediones with a spiro-heteroquaternary stereogenic center in good to excellent yields (up to 99%), with excellent levels of diastereo- and enantioselectivity (dr up to 99:1; ee up to 98%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b05f43a8427d673b9dfa00b4d1ee6448 https://doi.org/10.1002/chin.201607120 Zobrazit plný text záznamu Plný text