Die Interleukin-1α- und Interleukin-1β-Konzentration im Fruchtwasser während der Schwangerschaft unter besonderer Berücksichtigung von intrauteriner Keimbesiedlung
| Autor: | Winkler M, Rath W, Irene Pütz, Barbara Wienecke |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
education.field_of_study
Pregnancy medicine.medical_specialty Amniotic fluid medicine.diagnostic_test biology business.industry Obstetrics Population Obstetrics and Gynecology Gestational age medicine.disease biology.organism_classification Chorioamnionitis Andrology Ureaplasma Maternity and Midwifery medicine Amniocentesis Anaerobic bacteria education business |
| Zdroj: | Geburtshilfe und Frauenheilkunde. 56:640-644 |
| ISSN: | 1438-8804 0016-5751 |
| DOI: | 10.1055/s-2007-1022299 |
| Popis: | the Amniotic Cavity: Interleukin-1 is capable of stimulating prostaglandin production by intrauterine tissues and is a mediator of inflammation. On the other hand Interleukin-1 has been found in the amniotic fluid during normal human pregnancies. To understand the role of IL-1 in pregnancy and labour we measured IL-1α and IL-1β in amniotic fluid, using ELISA. Amniotic fluid was collected from 199 women during amniocentesis, hysterectomy during caesarean delivery or during amniotomy. Fluid of each sample was cultured for aerobic and anaerobic bacteria and for Mycoplasma hominis and Ureaplasma urea- lyticum. Different populations were identified according to the criteria gestational age, active labour, positive amniotic fluid culture. The second-trimester amniotic fluid contained only very low levels of IL-1α (4 pg/ml), increasing during the third trimester (weeks 28-37: 4-19 pg/ml, weeks 38-42: 5-53 pg/ml) before the onset of labour. In preterm labour and subsequent preterm delivery IL-1α is elevated in relation to the gestational age: 6-40 pg/ml, weeks 28-37. In labour at term no significantly higher IL-1α level than in term pregnancy with- out labour was seen. Only culture negative samples were included in this population. Interleukin-β was detectable in very low concentrations and in only 12% of the fluid samples. 25% of the women delivering at term had positive amniotic cultures without clinical evidence of infection. In these cases Interleukin-1α was significantly elevated (8-500 pg/ml); IL-1β was discovered in all cases at high concentrations (5-1000 pg/ml). Only in 3 out of 20 preterm deliveries bacteria were detected in the amniotic fluid, associated with elevated IL-1α and IL-1β levels. These findings suggest that IL-1α may play a role in the course of normal pregnancy. IL-1β is present in amniotic fluid and may mediate the onset of labour in intrauterine infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|