Tumor-induced alterations in lymph node lymph drainage identified by contrast-enhanced MRI

Autor:	Savannah C. Partridge, Ryan R. Sun, Sheila Ganti, Cheng Liang Liu, Alanna Ruddell, Sara B. Kirschbaum
Rok vydání:	2014
Předmět:	Pathology medicine.medical_specialty business.industry Melanoma Gadofosveset medicine.disease Subcutaneous injection medicine.anatomical_structure Lymphatic system Cortex (anatomy) Lymph drainage Medicine Radiology Nuclear Medicine and imaging business Lymph node Medulla medicine.drug
Zdroj:	Journal of Magnetic Resonance Imaging. 42:145-152
ISSN:	1053-1807
DOI:	10.1002/jmri.24754
Popis:	Background To use high resolution MRI lymphography to characterize altered tumor-draining lymph node (TDLN) lymph drainage in response to growth of aggressive tumors. Methods Six mice bearing B16-F10 melanomas in one rear footpad were imaged by 3.0 Tesla (T) MRI before and after subcutaneous injection of Gadofosveset trisodium (Gd-FVT) contrast agent into both rear feet. Gd-FVT uptake into the left and right draining popliteal LNs was quantified and compared using Wilcoxon signed-rank test. Fluorescent dextran lymphography compared patterns of LN lymph drainage with the pattern of immunostained lymphatic sinuses by fluorescence microscopy. Results TDLNs exhibited greater Gd-FVT uptake than contralateral uninvolved LNs, although this difference did not reach significance (P
Databáze:	OpenAIRE
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