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Publisher Summary This chapter discusses a study to examine the anti-curare action of 4-aminopyridine and 4-aminopyridine-like substances. In this study, the action of following substances was compared and analyzed: 4-aminopyridine, pyrocatechin, tetraethylammonium, and caffeine on the arrest of respiration and cardiac depression induced by aminoglycosidic antibiotics. Out of these four substances, caffeine was ineffective, tetraethylammonium had only cardiostimulating activity. Pyrocatechin did not affect the reduced contractility of the cardiac muscle, so that the only suitable substance was 4-aminopyridine. The latter had a similar effect as calcium, that is, it increased blood pressure and restored respiration. It acted even in the case when other therapeutic agents were ineffective, that is, in cases of calcium resistance and potentiated the effect of calcium and neostigmine. |
