Absolute Configuration of Two New 6-Alkylatedα-Pyrones (=2H-Pyran-2-ones) fromRavensara crassifolia
| Autor: | Ferenc Zsila, Miklós Simonyi, Sándor Antus, Kurt Hostettmann, Emerson Ferreira Queiroz, Guy Emmanuel Raoelison, Christian Terreaux, Adolphe Randriantsoa |
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| Rok vydání: | 2001 |
| Předmět: |
Circular dichroism
Stem bark Ravensara biology Stereochemistry Organic Chemistry Absolute configuration Fractionation Nuclear magnetic resonance spectroscopy biology.organism_classification Biochemistry Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Pyran Cladosporium cucumerinum Drug Discovery Physical and Theoretical Chemistry |
| Zdroj: | Helvetica Chimica Acta. 84:3470-3476 |
| ISSN: | 1522-2675 0018-019X |
| DOI: | 10.1002/1522-2675(20011114)84:11<3470::aid-hlca3470>3.0.co;2-k |
| Popis: | The stem bark CH2Cl2 extract of Ravensara crassifolia showed antifungal activity against the phytopathogenic fungus Cladosporium cucumerinum in a bioautographic TLC assay. Activity-guided fractionation afforded two new alpha -pyrones : (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one (1) and (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one (2). Their structures and absolute configurations were established by NMR spectroscopy, chemical methods, and CD spectroscopy. The antifungal activity against C. cucumerinum was determined for both compounds. |
| Databáze: | OpenAIRE |
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