| Autor: |
Gerhard Buchholz, Lothar Demisch, Peter Althoff, Kalus Demisch, Walter Magnet, Christoph Rosak |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
Psychiatry the State of the Art ISBN: 9781461294467 |
| DOI: |
10.1007/978-1-4613-2363-1_34 |
| Popis: |
Pirlindole is an antidepressive drug apparently acting by reversible inhibition of the monoamine oxidase type A in the central nervous system. Its preferential substrates are serotonin and norepinephrine. Changes in the levels of these amines in the central nervous system are often linked with hormonal changes mediated by the hypothalamic-pituitary axis. Of the hormones secreted by the pituitary gland, the growth hormone (GH) is of special interest as its secretion is stimulated by dopaminergic, noradrenergic and serotonergic neurons (1). Prolactin levels have been described as changing after the chronic administration of the irreversible type A and type B MAO inhibitors chlorgyline and pargyline, respectively (2), and after i.v. application of desipramine and chlorimipramine (3). LH and TSH are of further interest since their secretions seem to be influenced by aminergic neurons as well. In addition to pituitary hormones, we determined a variety of peripheral hormones as well in order to obtain more information on whether or not pirlindole interferes with other hormonal systems. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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