Development and in vitro Characterization of Intranasal Microemulsions of Sumatriptan Succinate for brain Targeting
| Autor: | R. Nagaraju, Damineni Saritha, P. Subhash Chandra Bose, Gokul Subramanian Ravi, U. Rajeswari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
02 engineering and technology Pharmacology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy In vitro Bioavailability Brain targeting 03 medical and health sciences 0302 clinical medicine Sumatriptan Succinate Pharmacology (medical) Microemulsion Nasal administration 0210 nano-technology Pharmacology Toxicology and Pharmaceutics (miscellaneous) |
| Zdroj: | Research Journal of Pharmacy and Technology. :2062-2068 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.52711/0974-360x.2021.00366 |
| Popis: | Microemulsions, by virtue of their lipophilic nature and low globule size, are widely explored as a delivery system to enhance uptake across mucosa. The main aim of the present investigation is to develop and in vitro characterization of intra nasal microemulsion of sumatriptan succinate for brain targeting for treating acute attack of migraine. The liquid microemulsion was prepared by dissolving drug (sumatriptan succinate) and mucoadhesive polymer sodium alginate in double distilled water. The prepared microemulsion was evaluated for particle size measurement, zeta potential measurement, viscosity measurement, centrifugation, drug content, optical clarity and in vitro drug release studies. The prepared formulations were showed particle size in the range of 106.2±2.03 to 282.8±2.51. The zeta potential value of the formulation ME2 showed −32.0mv indicating negative surface charge. The drug content showed in the range of 89.3±0.242 to 94.3±0.128. the optimized formulation showed in vitro drug release 74.2±0.95% at 12 h. and 86.23±0.41% at 24 hrs. From the results it was concluded that the prepared optimized microemulsion formulation as drug delivery system to improve bioavailability of the drugs like sumatriptan succinate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|