Evaluation of self-collected rectal swabs for the detection of bacteria responsible for sexually transmitted infections in a cohort of HIV-1-infected patients
| Autor: | Catherine Dhiver, Catherine Tamalet, Andreas Stein, Isabelle Ravaux, Philippe Colson, Christelle Tomei, Didier Raoult, Sophie Edouard, Amélie Menard, Hervé Tissot-Dupont |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty 030106 microbiology urologic and male genital diseases medicine.disease_cause Microbiology Asymptomatic 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine Proctitis biology Transmission (medicine) General Medicine biology.organism_classification medicine.disease female genital diseases and pregnancy complications 3. Good health Carriage Immunology Neisseria gonorrhoeae medicine.symptom Mycoplasma genitalium Chlamydia trachomatis Haemophilus ducreyi |
| Zdroj: | Journal of Medical Microbiology. 66:693-697 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.000481 |
| Popis: | Purpose. The standard approach to screening sexually transmitted infections (STIs) has often been restricted to urogenital specimens. Most current guidelines, however, also recommend testing extra-genital sites, including rectal locations, because asymptomatic rectal carriage of pathogens has often been reported. The aim of our study was to evaluate self-collected rectal swabs to screen bacterial STIs in HIV-infected patients in Marseille, France. Methodology. Between January 2014 and December 2015, 118 HIV-infected patients (93 males and 25 females) agreed to self-sample anal swabs for detection of bacterial STI. Detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum, Mycoplasma genitalium and Haemophilus ducreyi was performed using in-house qPCR assay. Results/Key findings. Bacterial STIs were found in 8 % (9/118) of the patients. C. trachomatis was the most commonly detected bacterium (4.2 %) followed by N. gonorrhoeae (2.5 %), M. genitalium (1.7 %) and T. pallidum (0.8 %). All the positive patients were males. The rectal carriage of pathogenic bacteria was fortuitously discovered for seven men (78 %) who did not present rectal signs of STIs and was suspected for two men who presented proctitis (22 %). Conclusion. In conclusion, testing extra-genital sites is crucial for the diagnosis of STIs in men and women presenting or not concomitant urogenital infections in order to detect asymptomatic carriage with the aim of controlling and preventing transmission to their sexual partners. |
| Databáze: | OpenAIRE |
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