Celiac Disease and Gyneco-obstetrics Complications: Can Serum Antibodies Modulate Tissue Transglutaminase Functions and Contribute to Clinical Pattern?
| Autor: | Cecilia Montenegro, Cecilia Sóñora, Natalia Del Río, Gisele Acosta, Elena Trucco, Ana Hernández, Florencia Muñoz |
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| Rok vydání: | 2011 |
| Předmět: |
Infertility
biology business.industry Tissue transglutaminase media_common.quotation_subject Immunology Obstetrics and Gynecology Disease medicine.disease medicine.disease_cause In vitro Autoimmunity Fibronectin Reproductive Medicine biology.protein Immunology and Allergy Medicine Antibody business Menstrual cycle media_common |
| Zdroj: | American Journal of Reproductive Immunology. 66:476-487 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2011.01020.x |
| Popis: | Citation Sonora C, Munoz F, Del Rio N, Acosta G, Montenegro C, Trucco E, Hernandez A. Celiac disease and gyneco-obstetrics complications: can serum antibodies modulate tissue transglutaminase functions and contribute to clinical pattern? Am J Reprod Immunol 2011; 66: 476–487 Problem Untreated celiac disease (CD) is often associated with early miscarriages, infertility, and alterations in menstrual cycle. Tissue transglutaminase (tTG) antibodies could be involved by interfering with tTG transamidating activity and/or biological functions mediated by its interaction with fibronectin (FN). Method of study The correlation between the presence of extra-digestive disorders and the reactivity of sera against tTG-FN and its effects on tTG transamidating activity was analyzed in a group or 50 women with recently diagnosed CD. Results Heterogeneous behavior was observed among serum samples derived from patients with different complaints, suggesting that differences in fine specificity patterns could condition clinical outcome. Sera from women with gynecological and/or obstetric problems induced significant inhibition of in vitro enzymatic activity in comparison with those without these kinds of disorders. Conclusions The significant correlation observed between serum effects and clinical profile suggests a putative involvement of tTG-specific antibodies in gynecological and/or obstetric disorders during active CD. |
| Databáze: | OpenAIRE |
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