Design and characterization of PLLA stents with Z-structure
| Autor: | Pei-hua Zhang, Cong-er Wang, Jiang Xiaotong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Polymers and Plastics medicine.medical_treatment Stent 02 engineering and technology 030204 cardiovascular system & hematology equipment and supplies 021001 nanoscience & nanotechnology medicine.disease Compression method 03 medical and health sciences Stenosis surgical procedures operative 0302 clinical medicine Restenosis medicine Chemical Engineering (miscellaneous) cardiovascular diseases 0210 nano-technology Radial Force Variation Biomedical engineering |
| Zdroj: | Textile Research Journal. 86:1701-1709 |
| ISSN: | 1746-7748 0040-5175 |
| DOI: | 10.1177/0040517515592813 |
| Popis: | Biodegradable intravascular stents could become totally degraded after supporting the stenosis diseased vascular without risks of thrombus and restenosis. As the earliest used biodegradable material on stents, poly-l-lactic acid (PLLA) has favorable mechanical and degradable performance. In this paper, poly-lactic acid was used as a stent material for the imitation of the S7 stent (Medtronic AVE, Minnesota, USA). The Z-structure stent was designed and constructed with textile methods by wounding and bonding the strut with a cylindrical mold. Poly-lactic acid Z-structure stents were made into different forms with two different bonding methods for the comparison of stent mechanical properties. In the meantime, polydiaxanon monofilament was used for the preparation of the Z-structure stent and WallStent to compare with poly-lactic acid stents. The stent radial force was tested by the platform compression method. Experimental results showed that the polydiaxanon Z-structure stent had a higher radial force than the poly-lactic acid ones because of better mechanical properties of the strut. Small-diameter stents expressed higher radial force, whereas stents with more crown rows had lower radial forces. Stents bonded with medical glue had higher radial force but lower fastness and inefficient self-expanded performance. The WallStent and Z-structure stent both had favorable elastic resilience performance, whereas the Z-structure stent performed better in compression resistance under large deformation |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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