Incidence of chromosomal anomalies detected by interphase FISH in chronic lymphoid leukemia

Autor:	Marie-Josée Le Bris, Marc De Braekeleer, Frédéric Morel, Nathalie Douet-Guilbert, Audrey Basinko
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty business.industry Incidence (epidemiology) Chronic lymphocytic leukemia Chronic lymphoid leukemia Hematology medicine.disease Oncology Medicine Fish Pharmacology (medical) Interphase business Trisomy
Zdroj:	International Journal of Hematologic Oncology. 4:133-141
ISSN:	2045-1407 2045-1393
Popis:	Aims & methods: We used interphase FISH to determine the incidence of chromosomal changes in 638 B-cell chronic lymphocytic leukemia patients. Results: Chromosomal abnormalities were found in some 75% of the patients. Del(13)(q14) was present in 57.3 and 57% of patients at diagnosis and during follow-up, respectively. It was followed by trisomy 12 (19 and 19.8% at diagnosis and during follow-up, respectively), del(11)(q22) (9.1 and 14.3% at diagnosis and during follow-up, respectively) and del(17)(p13) (2.8 and 12.4% at diagnosis and during follow-up, respectively). Discussion & conclusion: Our results correlate with those obtained in 55 studies reported in the literature. Trisomy 12 and del(13)(q14) are present in high proportions at diagnosis and are not enriched during progression, to the contrary of del(11)(q22) and del(17)(p13) that are markers of evolution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b015ae29af7ab724bac3073ebd1458bf https://doi.org/10.2217/ijh.15.19 Zobrazit plný text záznamu