Cytotoxic Activity of Perfluoroalkyl-Substituted Imidazoindazoles and Imidazobenzisoxazoles

Autor:	E. M. Tumar, O. V. Panibrat, V. G. Zinovich, Yu. A. Piven, S. E. Ogurtsova, Fedor A. Lakhvich, T. S. Khlebnikova
Rok vydání:	2021
Předmět:	Pharmacology Indazole Chemistry Cell cycle medicine.disease chemistry.chemical_compound Apoptosis Hepatocellular carcinoma Hepg2 cells Drug Discovery Carcinoma medicine Cancer research Cytotoxic T cell Cytotoxicity
Zdroj:	Pharmaceutical Chemistry Journal. 55:219-223
ISSN:	1573-9031 0091-150X
Popis:	The cytotoxic activity of perfluoroalkyl imidazoindazoles and imidazobenzisoxazoles with respect to MCF-7 (human breast carcinoma) and HepG2 cell lines (human hepatocellular carcinoma) was studied. The imidazoindazoles exhibited significant cytotoxicity against MCF-7 and HepG2 cell lines. 2,6-bis(4-Fluorophenyl)-4,4-dimethyl-8-trifluoromethyl-3,4,5,6-tetrahydroimidazo[4,5-e]indazole displayed the most pronounced cytotoxic action. Regioisomeric imidazobenzisoxazoles inhibited extensively growth of HepG2 cells. The mechanism of cytotoxic action can be related to the induction of apoptosis as a result of disruption of the cell cycle, in particular, arrest of HepG2 cells in the G2 phase and MCF-7 cells in the G1 phase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b01313b81b2f3b2f0bdae328bde2a66c https://doi.org/10.1007/s11094-021-02401-4 Zobrazit plný text záznamu Plný text ve formátu PDF