Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons*
| Autor: | James Stepenosky, Nancy F. Crum-Cianflone, Carolyn Brandt, Dylan Wessman, Sheila Medina, Gilbert Boswell, David Krause |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Cross-sectional study business.industry Health Policy Fatty liver Odds ratio medicine.disease Gastroenterology Surgery Coronary artery disease Infectious Diseases Interquartile range Internal medicine medicine Pharmacology (medical) Risk factor business Coronary atherosclerosis Subclinical infection |
| Zdroj: | HIV Medicine. 12:463-471 |
| ISSN: | 1464-2662 |
| Popis: | Background Cardiovascular disease is an increasing concern among HIV-infected persons and their providers. We determined if fatty liver disease is a marker for underlying coronary atherosclerosis among HIV-infected persons. Methods We performed a cross-sectional study in HIV-infected adults to evaluate the prevalence of and factors, including fatty liver disease, associated with subclinical coronary atherosclerosis. All participants underwent computed tomography for determination of coronary artery calcium (CAC; positive defined as a score >0) and fatty liver disease (defined as a liver-to-spleen ratio 100, the percentage with concurrent fatty liver disease was 8, 18 and 41%, respectively (P=0.001). In the multivariate model, CAC was associated with increasing age [odds ratio (OR) 4.3 per 10 years; P |
| Databáze: | OpenAIRE |
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