Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors
| Autor: | Martina Micheletti, Neil Cagney, Gregorio Rodriguez, Andrea Ducci, Weheliye Hashi Weheliye |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Fluid Flow and Transfer Processes
Physics Flow visualization Mechanical Engineering Computational Mechanics Rotational speed 02 engineering and technology Lyapunov exponent Mechanics Condensed Matter Physics 01 natural sciences 010305 fluids & plasmas Physics::Fluid Dynamics symbols.namesake 020401 chemical engineering Flow (mathematics) Particle image velocimetry Mechanics of Materials 0103 physical sciences symbols Dynamic mode decomposition Shaker 0204 chemical engineering Mixing (physics) |
| Zdroj: | Physics of Fluids. 30:033603 |
| ISSN: | 1089-7666 1070-6631 |
| DOI: | 10.1063/1.5016305 |
| Popis: | In this study, two mode decomposition techniques were applied and compared to assess the flow dynamics in an orbital shaken bioreactor (OSB) of cylindrical geometry and flat bottom: proper orthogonal decomposition and dynamic mode decomposition. Particle Image Velocimetry (PIV) experiments were carried out for different operating conditions including fluid height, h, and shaker rotational speed, N. A detailed flow analysis is provided for conditions when the fluid and vessel motions are in-phase (Fr = 0.23) and out-of-phase (Fr = 0.47). PIV measurements in vertical and horizontal planes were combined to reconstruct low order models of the full 3D flow and to determine its Finite-Time Lyapunov Exponent (FTLE) within OSBs. The combined results from the mode decomposition and the FTLE fields provide a useful insight into the flow dynamics and Lagrangian coherent structures in OSBs and offer a valuable tool to optimise bioprocess design in terms of mixing and cell suspension. |
| Databáze: | OpenAIRE |
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