Analysis of Crystal Size Dispersion Effects in a Continuous Coiled Tubular Crystallizer: Experiments and Modeling
| Autor: | Stefan Turek, Evren Bayraktar, Lukas Hohmann, Norbert Kockmann, Gerhard Schembecker, Otto Mierka, Thorsten Greinert, Kerstin Wohlgemuth |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Plug flow 010405 organic chemistry Flow (psychology) Crystal growth General Chemistry Mechanics 010402 general chemistry Condensed Matter Physics 01 natural sciences 0104 chemical sciences Volumetric flow rate law.invention Crystal law General Materials Science Growth rate Crystallization Dispersion (chemistry) |
| Zdroj: | Crystal Growth & Design. 18:1459-1473 |
| ISSN: | 1528-7505 1528-7483 |
| DOI: | 10.1021/acs.cgd.7b01383 |
| Popis: | Continuous processing gains importance in the fine chemical and pharmaceutical industries where crystallization is an important downstream operation. Seeded cooling crystallization of the l-alanine/water system was investigated under similar conditions, i.e., temperature interval, cooling rate, and seed material, both in a stirred batch vessel and in a continuous plug flow crystallizer in the coiled flow inverter (CFI) design with horizontal helical tube coils (ID = 4 mm) and frequent 90° bends of the coils. Short-cut calculations based on characteristic time scales and the Damkohler number allow for comparing the batch and continuous crystallization processes. The experimental results reveal crystal growth and growth rate dispersion to be dominating on the product crystal size distribution (CSD). However, at low flow rates of approximately 31 g min–1, a moving sediment flow of the slurry was present in the CFI crystallizer, resulting in further size dispersion effects. Elevated flow rates of approximatel... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|