VON RECKLINGHAUSEN′S DISEASE AND PHEOCHROMOCYTOMAS
| Autor: | McClellan M. Walther, Judi Herring, W. Marston Linehan, Erik Enquist, Harry R. Keiser |
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| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Journal of Urology. 162:1582-1586 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(05)68171-2 |
| Popis: | Purpose:: We review the literature and characterize the clinical findings of von Recklinghausen’sassociated pheochromocytoma.Materials and Methods:: A Grateful Med search for the years 1966 to 1999 was performed on the subjects, “von Recklinghausen” and “neurofibromatosis.” Articles from the Grateful Med search were then reviewed to identify older publications. Of 325 articles 118 are included in this review.Results:: Pheochromocytomas have been clinically identified in 0.1 to 5.7% of patients with von Recklinghausen’s disease. Mean patient age was 42 years (range 1.5 to 74) in 87 women and 61 men at presentation with pheochromocytoma. Of the 148 patients 84% had solitary adrenal tumors, 9.6% bilateral adrenal disease and 6.1% ectopic pheochromocytomas. Symptoms related to pheochromocytoma or hypertension were noted in 78% of the patients. Tumors secreted epinephrine and norepinephrine, and 87% demonstrated metaiodobenzylguanidine uptake. Of the 148 patients 6% died during pregnancy or a medical procedure... |
| Databáze: | OpenAIRE |
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