Fine-needle aspiration findings of Xp11 translocation renal cell carcinoma metastatic to a hilar lymph node
Autor: | Maria Luisa C. Policarpio-Nicolas, Amanda Gorena, Reima El Naili, Marlo M. Nicolas |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Histology medicine.medical_treatment TFE3 Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal medicine Eosinophilic medicine Lymph node medicine.diagnostic_test business.industry General Medicine medicine.disease Nephrectomy 030104 developmental biology Fine-needle aspiration medicine.anatomical_structure 030220 oncology & carcinogenesis Immunohistochemistry business Clear cell |
Zdroj: | Diagnostic Cytopathology. 45:456-462 |
ISSN: | 8755-1039 |
Popis: | Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the "MiT family translocation RCC" at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up. Fine-needle aspiration of the lymph node showed tumor cells with voluminous clear to eosinophilic cytoplasm, well-defined cell borders and hyperchromatic nuclei arranged in papillary architecture. Review of the prior nephrectomy specimen showed papillary cores surrounded by cells with voluminous clear to finely granular eosinophilic cytoplasm and distinct cell borders. Immunohistochemical stains performed on the nephrectomy specimen showed tumor positivity for CD10, E-cadherin, a-methylacyl coenzyme A racemase, and TFE3 supporting the diagnosis of Xp11 translocation renal cell carcinoma. Although this tumor was initially described predominantly in children, it could also occur in adults, as seen in this case. Familiarity with the cytologic findings of this tumor, use of immunohistochemical stains, or cytogenetic test to determine the type of gene fusion will be extremely useful in arriving at the correct diagnosis. Diagn. Cytopathol. 2017;45:456-462. © 2017 Wiley Periodicals, Inc. |
Databáze: | OpenAIRE |
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