Agave fructans enhance the effects of fermented milk products on obesity biomarkers: a randomised trial
| Autor: | M. Vega-Cárdenas, F. Martínez-Gutierrez, E.E. Lara-Ramírez, E. Reynaga-Hernandez, L. Yañez-Estrada, S. Ratering, S. Schnell, C.I. Godínez-Hernández, J.M. Vargas-Morales, D.P. Portales-Pérez |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Beneficial Microbes. 14:153-164 |
| ISSN: | 1876-2891 1876-2883 0542-3015 |
| DOI: | 10.3920/bm2022.0078 |
| Popis: | Dysbiosis has been implicated in childhood obesity. Oral intake of fermented milk containing Lacticaseibacillus casei strain Shirota preserves gut microbiota (GM) diversity in children and adults. This study was a double-blind trial involving 37 overweight or obese children aged 6-10 years. Children were followed over a 6-week intervention period in which they received different fermented milk products containing L. casei Shirota: 10 in the first group received just L. casei Shirota; 13 received L. casei Shirota with 3 g/day of inulin (L. casei+inulin); and 14 received L. casei Shirota with 3 g/day of fructans from Agave salmiana (L. casei+fructans). Principal component analysis showed the relationship between microbial abundance, GM metabolites, and other obesity-related markers. Supplementation with probiotics and synbiotics improved the HDL-cholesterol levels of overweight and obese children, although no changes in body composition were detected. We observed an increase in butyrate or propionate concentrations in the L. casei+fructans group compared to the end of the intervention (P The study was registered at ClinicalTrials.gov (ID: NCT05423015). |
| Databáze: | OpenAIRE |
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