Impact of the US Maternal Tetanus, Diphtheria, and Acellular Pertussis Vaccination Program on Preventing Pertussis in Infants <2 Months of Age: A Case-Control Evaluation
| Autor: | Paul R Cieslak, Melissa Lewis, Stacey W. Martin, Kathy Kudish, Nong Shang, Melissa McMahon, Karen Scherzinger, Amy Blain, James P. Watt, Tami H. Skoff, Shelley M. Zansky |
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| Rok vydání: | 2017 |
| Předmět: |
Microbiology (medical)
Pregnancy Pediatrics medicine.medical_specialty Tetanus business.industry Diphtheria medicine.disease Confidence interval Vaccination 03 medical and health sciences 0302 clinical medicine Infectious Diseases 030225 pediatrics medicine Pertussis vaccine 030212 general & internal medicine business Diphtheria-Tetanus-acellular Pertussis Vaccines Whooping cough medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 65:1977-1983 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background Infants aged Methods We conducted a case-control evaluation among pertussis cases Results A total of 240 cases and 535 controls were included; 17 (7.1%) case mothers and 90 (16.8%) control mothers received Tdap during the third trimester of pregnancy. The multivariable VE estimate for Tdap administered during the third trimester of pregnancy was 77.7% (95% confidence interval [CI], 48.3%-90.4%); VE increased to 90.5% (95% CI, 65.2%-97.4%) against hospitalized cases. Conclusions Vaccination during pregnancy is an effective way to protect infants during the early months of life. With a continuing resurgence in pertussis, efforts should focus on maximizing Tdap uptake among pregnant women. |
| Databáze: | OpenAIRE |
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